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Multiple biomarker panels for early detection of breast cancer in peripheral blood.

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Multiple biomarker panels for early detection of breast cancer in peripheral blood.

Biomed Res Int. 2013;2013:781618

Authors: Zhang F, Deng Y, Drabier R

Abstract
Detecting breast cancer at early stages can be challenging. Traditional mammography and tissue microarray that have been studied for early breast cancer detection and prediction have many drawbacks. Therefore, there is a need for more reliable diagnostic tools for early detection of breast cancer due to a number of factors and challenges. In the paper, we presented a five-marker panel approach based on SVM for early detection of breast cancer in peripheral blood and show how to use SVM to model the classification and prediction problem of early detection of breast cancer in peripheral blood. We found that the five-marker panel can improve the prediction performance (area under curve) in the testing data set from 0.5826 to 0.7879. Further pathway analysis showed that the top four five-marker panels are associated with signaling, steroid hormones, metabolism, immune system, and hemostasis, which are consistent with previous findings. Our prediction model can serve as a general model for multibiomarker panel discovery in early detection of other cancers.

PMID: 24371830 [PubMed - indexed for MEDLINE]

mTOR signaling inhibition modulates macrophage/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after focal ischemia.

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mTOR signaling inhibition modulates macrophage/microglia-mediated neuroinflammation and secondary injury via regulatory T cells after focal ischemia.

J Immunol. 2014 Jun 15;192(12):6009-19

Authors: Xie L, Sun F, Wang J, Mao X, Xie L, Yang SH, Su DM, Simpkins JW, Greenberg DA, Jin K

Abstract
Signaling by the mammalian target of rapamycin (mTOR) plays an important role in the modulation of both innate and adaptive immune responses. However, the role and underlying mechanism of mTOR signaling in poststroke neuroinflammation are largely unexplored. In this study, we injected rapamycin, a mTOR inhibitor, by the intracerebroventricular route 6 h after focal ischemic stroke in rats. We found that rapamycin significantly reduced lesion volume and improved behavioral deficits. Notably, infiltration of γδ T cells and granulocytes, which are detrimental to the ischemic brain, was profoundly reduced after rapamycin treatment, as was the production of proinflammatory cytokines and chemokines by macrophages and microglia. Rapamycin treatment prevented brain macrophage polarization toward the M1 type. In addition, we also found that rapamycin significantly enhanced anti-inflammation activity of regulatory T cells (Tregs), which decreased production of proinflammatory cytokines and chemokines by macrophages and microglia. Depletion of Tregs partially elevated macrophage/microglia-induced neuroinflammation after stroke. Our data suggest that rapamycin can attenuate secondary injury and motor deficits after focal ischemia by enhancing the anti-inflammation activity of Tregs to restrain poststroke neuroinflammation.

PMID: 24829408 [PubMed - indexed for MEDLINE]

Using modified approaches on marginal regression analysis of longitudinal data with time-dependent covariates

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Zhou, Y. | Lefante, J. | Rice, J. | Chen, S.
Publication year: 2014
Journal / Book title: Statistics in Medicine

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PTEN degradation after ischemic stroke: A double-edged sword

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Li, W. | Huang, R. | Chen, Z. | Yan, L.-J. | Simpkins, J.W. | Yang, S.-H.
Publication year: 2014
Journal / Book title: Neuroscience

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What Role Does Sleep Play in Weight Gain in the First Semester of University?

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Roane, B.M. | Seifer, R. | Sharkey, K.M. | Van Reen, E. | Bond, T.L.Y. | Raffray, T. | Carskadon, M.A.
Publication year: 2014
Journal / Book title: Behavioral Sleep Medicine

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Platinum(IV) cisplatin derivative trans, cis, cis-bis(heptanoato)amine(cyclohexylamine)dichloridoplatinum(IV) has an enhanced therapeutic index compared to cisplatin for the treatment of non-small cell lung cancer

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Shi, Y. | Koneru, B. | Redfearn, W. | Miller, M.L. | Myers, L. | Di Pasqua, A.J.
Publication year: 2014
Journal / Book title: Inorganica Chimica Acta

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A useful mouse model of glucocorticoid-induced ocular hypertension

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Clark, A.F.
Publication year: 2014
Journal / Book title: Investigative Ophthalmology and Visual Science

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Neuronal injury from cardiac arrest: aging years in minutes

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Cherry, B.H. | Sumien, N. | Mallet, R.T.
Publication year: 2014
Journal / Book title: AGE

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Capsule Commentary on Albrecht et al., Hospital Discharge Instructions: Comprehension and Compliance Among Older Adults

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Tak, H.J.
Publication year: 2014
Journal / Book title: Journal of General Internal Medicine

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Environmental lead exposure is associated with visit-to-visit systolic blood pressure variability in the US adults

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Faramawi, M.F. | Delongchamp, R. | Lin, Y.-S. | Liu, Y. | Abouelenien, S. | Fischbach, L. | Jadhav, S.
Publication year: 2014
Journal / Book title: International Archives of Occupational and Environmental Health

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Erratum to: Pressure cycling technology (PCT) reduces effects of inhibitors of the PCR

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Marshall, P.L. | King, J.L. | Lawrence, N.P. | Lazarev, A. | Gross, V.S. | Budowle, B.
Publication year: 2014
Journal / Book title: International Journal of Legal Medicine

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Generation of vertical angular momentum in single, double, and triple-turn pirouette en dehors in ballet

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Kim, J. | Wilson, M.A. | Singhal, K. | Gamblin, S. | Suh, C.-Y. | Kwon, Y.-H.
Publication year: 2014
Journal / Book title: Sports Biomechanics

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Suicide Risk and Mental Health Co-morbidities in a Probationer Population

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Cardarelli, R. | Balyakina, E. | Malone, K. | Fulda, K.G. | Ellison, M. | Sivernell, R. | Shabu, T.
Publication year: 2014
Journal / Book title: Community Mental Health Journal

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Kinetic comparison of older men and women during walk-to-stair descent transition

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Singhal, K. | Kim, J. | Casebolt, J. | Lee, S. | Han, K.H. | Kwon, Y.-H.
Publication year: 2014
Journal / Book title: Gait and Posture

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Application of screening experimental designs to assess chromatographic isotope effect upon isotope-coded derivatization for quantitative liquid chromatography-mass spectrometry

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Szarka, S. | Prokai-Tatrai, K. | Prokai, L.
Publication year: 2014
Journal / Book title: Analytical Chemistry

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Astrocyte elevated gene-1 is a novel modulator of HIV-1-associated neuroinflammation via regulation of nuclear factor-κB signaling and excitatory amino acid transporter-2 repression

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Vartak-Sharma, N. | Gelman, B.B. | Joshi, C. | Borgamann, K. | Ghorpade, A.
Publication year: 2014
Journal / Book title: Journal of Biological Chemistry

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The Association between Patient-Centered Attributes of Care and Patient Satisfaction

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Tak, H. | Ruhnke, G.W. | Shih, Y.-C.T.
Publication year: 2014
Journal / Book title: The Patient - Patient-Centered Outcomes Research

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Evidence of brain tumor stem progenitor-like cells with low proliferative capacity in human benign pituitary adenoma

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Chen, L. | Ye, H. | Wang, X. | Tang, X. | Mao, Y. | Zhao, Y. | Wu, Z. | Mao, X.O. | Xie, L. | Jin, K. | Yao, Y.
Publication year: 2014
Journal / Book title: Cancer Letters

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Total Cholesterol and Neuropsychiatric Symptoms in Alzheimer's Disease: The Impact of Total Cholesterol Level and Gender

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Hall, J.R. | Wiechmann, A.R. | Johnson, L.A. | Edwards, M. | Barber, R.C. | Cunningham, R. | Singh, M. | O'Bryant, S.E.
Publication year: 2014
Journal / Book title: Dementia and Geriatric Cognitive Disorders

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The role of 5-HT2A, 5-HT2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice

Latest UNTHSC Articles in Scopus - Wed, 08/20/2014 - 8:05am
Author(s):Carbonaro, T.M. | Eshleman, A.J. | Forster, M.J. | Cheng, K. | Rice, K.C. | Gatch, M.B.
Publication year: 2014
Journal / Book title: Psychopharmacology

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