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Cell-cell contact viral transfer contributes to HIV infection and persistence in astrocytes.

Cell-cell contact viral transfer contributes to HIV infection and persistence in astrocytes.

J Neurovirol. 2014 Dec 19;

Authors: Luo X, He JJ

Abstract
Astrocytes are the most abundant cells in the central nervous system and play important roles in human immunodeficiency virus (HIV)/neuro-acquired immunodeficiency syndrome. Detection of HIV proviral DNA, RNA, and early gene products but not late structural gene products in astrocytes in vivo and in vitro indicates that astrocytes are susceptible to HIV infection albeit in a restricted manner. We as well as others have shown that cell-free HIV is capable of entering CD4- astrocytes through human mannose receptor-mediated endocytosis. In this study, we took advantage of several newly developed fluorescence protein-based HIV reporter viruses and further characterized HIV interaction with astrocytes. First, we found that HIV was successfully transferred to astrocytes from HIV-infected CD4+ T cells in a cell-cell contact- and gp120-dependent manner. In addition, we demonstrated that, compared to endocytosis-mediated cell-free HIV entry and subsequent degradation of endocytosed virions, the cell-cell contact between astrocytes and HIV-infected CD4+ T cells led to robust HIV infection of astrocytes but retained the restricted nature of viral gene expression. Furthermore, we showed that HIV latency was established in astrocytes. Lastly, we demonstrated that infectious progeny HIV was readily recovered from HIV latent astrocytes in a cell-cell contact-mediated manner. Taken together, our studies point to the importance of the cell-cell contact-mediated HIV interaction with astrocytes and provide direct evidence to support the notion that astrocytes are HIV latent reservoirs in the central nervous system.

PMID: 25522787 [PubMed - as supplied by publisher]

The link between sleep disturbance and depression among Mexican Americans: a Project FRONTIER study.

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The link between sleep disturbance and depression among Mexican Americans: a Project FRONTIER study.

J Clin Sleep Med. 2014 Apr 15;10(4):427-31

Authors: Roane BM, Johnson L, Edwards M, Hall J, Al-Farra S, O'Bryant SE

Abstract
OBJECTIVE: To examine the link between disturbed sleep and depression scores in Mexican Americans and non-Hispanic Whites.
METHODS: Data were analyzed for 566 participants (45% Mexican Americans) who were part of a rural healthcare study, Project FRONTIER. Mean age was 55.5 years for Mexican Americans (70% female) and 65.6 years for non-Hispanic Whites (69% female). Self-reported sleep disturbance was entered as the predictor, GDS-30 total and factor scores as the outcome variables, and age, sex, education, BMI, and medical diagnoses (hyperlipidemia, diabetes mellitus, and hypertension) entered as covariates.
RESULTS: Mexican Americans reported higher rates of sleep disturbances (25%) than non-Hispanic whites (17%). Sleep disturbances were significantly associated with GDS-30 total scores and the factors Dysphoria and Cognitive Impairment in both Mexican Americans and non-Hispanic whites.
CONCLUSIONS: In this study, Mexican Americans reported higher rates of sleep disturbances than non-Hispanic whites. Disturbed sleep was positively associated with depression and the factor scores for Dysphoria and Cognitive Impairment in both groups. Given the paucity of research on sleep disorders in Mexican Americans, identifying what sleep disorders are present and the impact treating these sleep disorders have on depression warrant further investigation.

PMID: 24733989 [PubMed - indexed for MEDLINE]

Arsenic exposure, hyperuricemia, and gout in US adults

Latest UNTHSC Articles in Scopus - Sat, 12/20/2014 - 11:31pm
Author(s):Kuo, C.-C. | Weaver, V. | Fadrowski, J.J. | Lin, Y.-S. | Guallar, E. | Navas-Acien, A.
Publication year: 2015
Journal / Book title: Environment International

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STRait Razor v2.0: The improved STR Allele Identification Tool-Razor

Latest UNTHSC Articles in Scopus - Sat, 12/20/2014 - 11:31pm
Author(s):Warshauer, D.H. | King, J.L. | Budowle, B.
Publication year: 2015
Journal / Book title: Forensic Science International: Genetics

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Urine osmolality in the US population: Implications for environmental biomonitoring

Latest UNTHSC Articles in Scopus - Sat, 12/20/2014 - 11:31pm
Author(s):Yeh, H.-C. | Lin, Y.-S. | Kuo, C.-C. | Weidemann, D. | Weaver, V. | Fadrowski, J. | Neu, A. | Navas-Acien, A.
Publication year: 2015
Journal / Book title: Environmental Research

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Exosome-associated hepatitis C virus in cell cultures and patient plasma

Latest UNTHSC Articles in Scopus - Sat, 12/20/2014 - 11:31pm
Author(s):Liu, Z. | Zhang, X. | Yu, Q. | He, J.J.
Publication year: 2014
Journal / Book title: Biochemical and Biophysical Research Communications

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Nanofluidity of fatty acid hydrocarbon chains as monitored by benchtop time-domain nuclear magnetic resonance

Latest UNTHSC Articles in Scopus - Sat, 12/20/2014 - 11:31pm
Author(s):Robinson, M.D. | Cistola, D.P.
Publication year: 2014
Journal / Book title: Biochemistry

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Cost-consequence analysis of cause of death investigation in Finland and in Denmark

Latest UNTHSC Articles in Scopus - Sat, 12/20/2014 - 11:31pm
Author(s):Ylijoki-Sørensen, S. | Boldsen, J.L. | Lalu, K. | Sajantila, A. | Baandrup, U. | Boel, L.W.T. | Ehlers, L.H. | Bøggild, H.
Publication year: 2014
Journal / Book title: Forensic Science International

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Epidemiological profiles of hand, foot, and mouth disease, including meteorological factors, in Suzhou, China

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Author(s):Chen, Z. | Sun, H. | Yan, Y. | Wang, Y. | Zhu, C. | Zhou, W. | Huang, L. | Wang, M. | Mize, M. | Tian, J. | Ji, W.
Publication year: 2014
Journal / Book title: Archives of Virology

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Massively parallel sequencing of forensically relevant single nucleotide polymorphisms using TruSeq™ forensic amplicon

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Author(s):Warshauer, D.H. | Davis, C.P. | Holt, C. | Han, Y. | Walichiewicz, P. | Richardson, T. | Stephens, K. | Jager, A. | King, J. | Budowle, B.
Publication year: 2014
Journal / Book title: International Journal of Legal Medicine

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Role of insulin resistance in Alzheimer’s disease

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Author(s):Cai, Z. | Xiao, M. | Chang, L. | Yan, L.-J.
Publication year: 2014
Journal / Book title: Metabolic Brain Disease

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Coding ill-defined and unknown cause of death is 13 times more frequent in Denmark than in Finland

Latest UNTHSC Articles in Scopus - Sat, 12/20/2014 - 11:31pm
Author(s):Ylijoki-Sørensen, S. | Sajantila, A. | Lalu, K. | Bøggild, H. | Boldsen, J.L. | Boel, L.W.T.
Publication year: 2014
Journal / Book title: Forensic Science International

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Sigma-1 receptor stimulation protects retinal ganglion cells from ischemia-like insult through the activation of extracellular-signal-regulated kinases 1/2

Latest UNTHSC Articles in Scopus - Sat, 12/20/2014 - 11:31pm
Author(s):Mueller, B.H. | Park, Y. | Ma, H.-Y. | Dibas, A. | Ellis, D.Z. | Clark, A.F. | Yorio, T.
Publication year: 2014
Journal / Book title: Experimental Eye Research

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Autopsy rate in suicide is low among elderly in Denmark compared with Finland

Latest UNTHSC Articles in Scopus - Sat, 12/20/2014 - 11:31pm
Author(s):Ylijoki-Sørensen, S. | Boldsen, J.L. | Boel, L.W.T. | Bøggild, H. | Lalu, K. | Sajantila, A.
Publication year: 2014
Journal / Book title: Forensic Science International

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Resident Assistant Training Program for Increasing Alcohol, Other Drug, and Mental Health First-Aid Efforts

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Author(s):Thombs, D.L. | Gonzalez, J.M.R. | Osborn, C.J. | Rossheim, M.E. | Suzuki, S.
Publication year: 2014
Journal / Book title: Prevention Science

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Δ9-Tetrahydrocannabinol-like discriminative stimulus effects of compounds commonly found in K2/Spice

Latest UNTHSC Articles in Scopus - Sat, 12/20/2014 - 11:31pm
Author(s):Gatch, M.B. | Forster, M.J.
Publication year: 2014
Journal / Book title: Behavioural Pharmacology

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Methylene blue promotes quiescence of rat neural progenitor cells

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Author(s):Xie, L. | Choudhury, G.R. | Wang, J. | Park, Y. | Liu, R. | Yuan, F. | Zhang, C.-L. | Yorio, T. | Jin, K. | Yang, S.-H.
Publication year: 2014
Journal / Book title: Frontiers in Cellular Neuroscience

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Discriminative and locomotor effects of five synthetic cathinones in rats and mice

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Author(s):Gatch, M.B. | Rutledge, M.A. | Forster, M.J.
Publication year: 2014
Journal / Book title: Psychopharmacology

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Cognitive Set Shifting Deficits and Their Relationship to Repetitive Behaviors in Autism Spectrum Disorder

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Author(s):Miller, H.L. | Ragozzino, M.E. | Cook, E.H. | Sweeney, J.A. | Mosconi, M.W.
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Journal / Book title: Journal of Autism and Developmental Disorders

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Pregnancy Research on Osteopathic Manipulation Optimizing Treatment Effects: the PROMOTE study

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Author(s):Hensel, K.L. | Buchanan, S. | Brown, S.K. | Rodriguez, M. | Cruser, d.A.
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Journal / Book title: American Journal of Obstetrics and Gynecology

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