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Acute aerobic exercise mediates G protein-coupled receptor kinase 2 expression in human PBMCs

Latest UNTHSC Articles in Scopus - 8 hours 21 min ago
Author(s):Huang, C.-J. | Slusher, A.L. | Whitehurst, M. | Wells, M. | Mock, J.T. | Maharaj, A. | Shibata, Y.
Publication year: 2015
Journal / Book title: Life Sciences

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A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium

Latest UNTHSC Articles in Scopus - 8 hours 21 min ago
Author(s):Mukerjee, A. | Iyidogan, P. | Castellanos-Gonzalez, A. | Cisneros, J.A. | Czyzyk, D. | Ranjan, A.P. | Jorgensen, W.L. | White, A.C. | Vishwanatha, J.K. | Anderson, K.S.
Publication year: 2015
Journal / Book title: Bioorganic and Medicinal Chemistry Letters

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Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death.

Recent Research Articles from UNTHSC - Fri, 08/28/2015 - 3:29am
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Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death.

Mol Neurodegener. 2015;10(1):40

Authors: Choudhury S, Liu Y, Clark AF, Pang IH

Abstract
BACKGROUND: Axonal injury of the optic nerve (ON) is involved in various ocular diseases, such as glaucoma and traumatic optic neuropathy, which leads to apoptotic death of retinal ganglion cells (RGCs) and loss of vision. Caspases have been implicated in RGC pathogenesis. However, the role of caspase-7, a functionally unique caspase, in ON injury and RGC apoptosis has not been reported previously. The purpose of this study is to evaluate the role of caspase-7 in ON injury-induced RGC apoptosis.
RESULTS: C57BL/6 (wildtype, WT) and caspase-7 knockout (Casp7 (-/-) ) mice were used. We show that ON crush activated caspase-7 and calpain-1, an upstream activator of caspase-7, in mouse RGCs, as well as hydrolysis of kinectin and co-chaperone P23, specific substrates of caspase-7. ON crush caused a progressive loss of RGCs to 28 days after injury. Knockout of caspase-7 partially and significantly protected against the ON injury-induced RGC loss; RGC density at 28 days post ON crush in Casp7 (-/-) mice was approximately twice of that in WT ON injured retinas. Consistent with changes in RGC counts, spectral-domain optical coherence tomography analysis revealed that ON crush significantly reduced the in vivo thickness of the ganglion cell complex layer (including ganglion cell layer, nerve fiber layer, and inner plexiform layer) in the retina. The ON crush-induced thinning of retinal layer was significantly ameliorated in Casp7 (-/-) mice when compared to WT mice. Moreover, electroretinography analysis demonstrated a decline in the positive component of scotopic threshold response amplitude in ON crushed eyes of the WT mice, whereas this RGC functional response was significantly higher in Casp7 (-/-) mice at 28 days post injury.
CONCLUSION: Altogether, our findings indicate that caspase-7 plays a critical role in ON injury-induced RGC death, and inhibition of caspase-7 activity may be a novel therapeutic strategy for glaucoma and other neurodegenerative diseases of the retina.

PMID: 26306916 [PubMed - in process]

The relationship between electronic goal reminders and subsequent drug use and treatment initiation in a criminal justice setting

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Spohr, S.A. | Taxman, F.S. | Walters, S.T.
Publication year: 2015
Journal / Book title: Addictive Behaviors

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Total testosterone and neuropsychiatric symptoms in elderly men with Alzheimer's disease

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Hall, J.R. | Wiechmann, A.R. | Cunningham, R.L. | Johnson, L.A. | Edwards, M. | Barber, R.C. | Singh, M. | Winter, S. | O'Bryant, S.E.
Publication year: 2015
Journal / Book title: Alzheimer's Research and Therapy

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Two novel high performing composite PMMA-CaP cements for vertebroplasty: An ex vivo animal study

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Aghyarian, S. | Hu, X. | Lieberman, I.H. | Kosmopoulos, V. | Kim, H.K.W. | Rodrigues, D.C.
Publication year: 2015
Journal / Book title: Journal of the Mechanical Behavior of Biomedical Materials

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Transcription Factor Brn-3b Overexpression Enhances Neurite Outgrowth in PC12 Cells Under Condition of Hypoxia

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Phatak, N.R. | Stankowska, D.L. | Krishnamoorthy, R.R.
Publication year: 2015
Journal / Book title: Cellular and Molecular Neurobiology

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Minimum Information about a Biosynthetic Gene cluster

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Medema, M.H. | Kottmann, R. | Yilmaz, P. | Cummings, M. | Biggins, J.B. | Blin, K. | De Bruijn, I. | Chooi, Y.H. | Claesen, J. | Coates, R.C. | Cruz-Morales, P. | Duddela, S. | Düsterhus, S. | Edwards, D.J. | Fewer, D.P. | Garg, N. | Geiger, C. | Gomez-Escribano, J.P. | Greule, A. | Hadjithomas, M. | Haines, A.S. | Helfrich, E.J.N. | Hillwig, M.L. | Ishida, K. | Jones, A.C. | Jones, C.S. | Jungmann, K. | Kegler, C. | Kim, H.U. | Kötter, P. | Krug, D. | Masschelein, J. | Melnik, A.V. | Mantovani, S.M. | Monroe, E.A. | Moore, M. | Moss, N. | Nützmann, H.-W. | Pan, G. | Pati, A. | Petras, D. | Reen, F.J. | Rosconi, F. | Rui, Z. | Tian, Z. | Tobias, N.J. | Tsunematsu, Y. | Wiemann, P. | Wyckoff, E. | Yan, X. | Yim, G. | Yu, F. | Xie, Y. | Aigle, B. | Apel, A.K. | Balibar, C.J. | Balskus, E.P. | Barona-Gómez, F. | Bechthold, A. | Bode, H.B. | Borriss, R. | Brady, S.F. | Brakhage, A.A. | Caffrey, P. | Cheng, Y.Q. | Clardy, J. | Cox, R.J. | De Mot, R. | Donadio, S. | Donia, M.S. | Van Der Donk, W.A. | Dorrestein, P.C. | Doyle, S. | Driessen, A.J.M. | Ehling-Schulz, M. | Entian, K.-D. | Fischbach, M.A. | Gerwick, L. | Gerwick, W.H. | Gross, H. | Gust, B. | Hertweck, C. | Höfte, M. | Jensen, S.E. | Ju, J. | Katz, L. | Kaysser, L. | Klassen, J.L. | Keller, N.P. | Kormanec, J. | Kuipers, O.P. | Kuzuyama, T. | Kyrpides, N.C. | Kwon, H.-J. | Lautru, S. | Lavigne, R. | Lee, C.Y. | Linquan, B. | Liu, X. | Liu, W. | Luzhetskyy, A. | Mahmud, T. | Mast, Y. | Méndez, C. | Metsä-Ketelä, M. | Micklefield, J. | Mitchell, D.A. | Moore, B.S. | Moreira, L.M. | Müller, R. | Neilan, B.A. | Nett, M. | Nielsen, J. | O'Gara, F. | Oikawa, H. | Osbourn, A. | Osburne, M.S. | Ostash, B. | Payne, S.M. | Pernodet, J.-L. | Petricek, M. | Piel, J. | Ploux, O. | Raaijmakers, J.M. | Salas, J.A. | Schmitt, E.K. | Scott, B. | Seipke, R.F. | Shen, B. | Sherman, D.H. | Sivonen, K. | Smanski, M.J. | Sosio, M. | Stegmann, E. | Süssmuth, R.D. | Tahlan, K. | Thomas, C.M. | Tang, Y. | Truman, A.W. | Viaud, M. | Walton, J.D. | Walsh, C.T. | Weber, T. | Van Wezel, G.P. | Wilkinson, B. | Willey, J.M. | Wohlleben, W. | Wright, G.D. | Ziemert, N. | Zhang, C. | Zotchev, S.B. | Breitling, R. | Takano, E. | Glöckner, F.O.
Publication year: 2015
Journal / Book title: Nature Chemical Biology

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MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Kpetemey, M. | Dasgupta, S. | Rajendiran, S. | Das, S. | Gibbs, L.D. | Shetty, P. | Gryczynski, Z. | Vishwanatha, J.K.
Publication year: 2015
Journal / Book title: Molecular Cancer

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Acute inhalation of vaporized nicotine increases arterial pressure in young non-smokers: a pilot study

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Cooke, W.H. | Pokhrel, A. | Dowling, C. | Fogt, D.L. | Rickards, C.A.
Publication year: 2015
Journal / Book title: Clinical Autonomic Research

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Δ9-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids found on the gray market

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Gatch, M.B. | Forster, M.J.
Publication year: 2015
Journal / Book title: Behavioural Pharmacology

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The effects of metal ion PCR inhibitors on results obtained with the Quantifiler<sup>®</sup> Human DNA Quantification Kit

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Combs, L.G. | Warren, J.E. | Huynh, V. | Castaneda, J. | Golden, T.D. | Roby, R.K.
Publication year: 2015
Journal / Book title: Forensic Science International: Genetics

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Assessment of subunit-dependent direct gating and allosteric modulatory effects of carisoprodol at GABA<inf>A</inf> receptors

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Kumar, M. | González, L.A. | Dillon, G.H.
Publication year: 2015
Journal / Book title: Neuropharmacology

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Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Ryou, M.-G. | Choudhury, G.R. | Li, W. | Winters, A. | Yuan, F. | Liu, R. | Yang, S.-H.
Publication year: 2015
Journal / Book title: Neuroscience

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Constrictor prostanoids and uridine adenosine tetraphosphate: Vascular mediators and therapeutic targets in hypertension and diabetes

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Matsumoto, T. | Goulopoulou, S. | Taguchi, K. | Tostes, R.C. | Kobayashi, T.
Publication year: 2015
Journal / Book title: British Journal of Pharmacology

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Alcohol Sales to Youth: Data from Rural Communities Within the Cherokee Nation

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Lynne-Landsman, S.D. | Kominsky, T.K. | Livingston, M.D. | Wagenaar, A.C. | Komro, K.A.
Publication year: 2015
Journal / Book title: Prevention Science

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Tip110 binding to U6 small nuclear RNA and its participation in pre-mRNA splicing

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Liu, Y. | Liu, J. | Wang, Z. | He, J.J.
Publication year: 2015
Journal / Book title: Cell and Bioscience

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Contra-directional expression of serum homocysteine and uric acid as important biomarkers of multiple system atrophy severity: A cross-sectional study

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Chen, D. | Wei, X. | Zou, J. | Wang, R. | Liu, X. | Xu, X. | Lu, J. | Wang, Z. | Tang, B. | Wang, B. | Jin, K. | Wang, Q.
Publication year: 2015
Journal / Book title: Frontiers in Cellular Neuroscience

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Vestiges of an ancient border in the contemporary genetic diversity of North-Eastern Europe

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Neuvonen, A.M. | Putkonen, M. | Översti, S. | Sundell, T. | Onkamo, P. | Sajantila, A. | Palo, J.U.
Publication year: 2015
Journal / Book title: PLoS ONE

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Motivational tools to improve probationer treatment outcomes

Latest UNTHSC Articles in Scopus - Thu, 08/27/2015 - 11:30pm
Author(s):Taxman, F.S. | Walters, S.T. | Sloas, L.B. | Lerch, J. | Rodriguez, M.
Publication year: 2015
Journal / Book title: Contemporary Clinical Trials

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