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Kienböck Disease: Moving Forward.

Recent Research Articles from UNTHSC - Sat, 04/09/2016 - 06:43

Kienböck Disease: Moving Forward.

J Hand Surg Am. 2016 Apr 4;

Authors: Lichtman DM, Pientka WF, Bain GI

Abstract
Over the past decade, a plethora of new information has been reported regarding etiology, natural history, classification, and treatment options for lunate osteonecrosis. New disease classifications have been described based on advanced imaging determination of lunate viability as well as a cartilage-based arthroscopic classification. Here we review the newest literature regarding Kienböck disease and present a new treatment algorithm that incorporates the traditional osseous classification system with a perfusion/viability classification and an articular cartilage-based classification.

PMID: 27055625 [PubMed - as supplied by publisher]

Associations between time spent sitting and cancer-related biomarkers in postmenopausal women: an exploration of effect modifiers.

Recent Research Articles from UNTHSC - Sat, 04/09/2016 - 06:43
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Associations between time spent sitting and cancer-related biomarkers in postmenopausal women: an exploration of effect modifiers.

Cancer Causes Control. 2014 Nov;25(11):1427-37

Authors: Paxton RJ, Jung SY, Vitolins MZ, Fenton J, Paskett E, Pollak M, Hays-Grudo J, Hursting SD, Chang S

Abstract
PURPOSE: Despite evidence that prolonged periods of sitting may influence biological mediators of cancer development, few studies have considered these relationships in a cancer-specific context.
METHODS: This cross-sectional study included 755 postmenopausal women enrolled in an ancillary study of the Women's Health Initiative. Plasma levels of Insulin-like growth factor-I (IGF-I), IGF-binding protein-3, leptin, insulin, C-peptide, C-reactive protein (CRP), and Interleukin (IL)-6 were measured. The time spent sitting per day was categorized as quartiles (Qs). The relationships between sedentary time and biomarkers were modified by race, physical activity, and exogenous estrogen use.
RESULTS: IGF-I levels among African American (AA) women were higher than those of white women across the Qs of sedentary time. Likewise, IL-6 levels in AA women were higher than those in white women at Q3 and Q4 of sedentary time. IGFBP-3 levels were higher and insulin levels were lower across the Qs of sedentary time among women meeting guidelines for physical activity than women who were not. Additionally, CRP levels were higher among estrogen users than nonusers at Q1, Q2, and Q4 of sedentary time.
CONCLUSIONS: These results suggest that relationship between time spent sitting and cancer-related biomarkers may not be simply linear, but differ in the context of effect modifiers.

PMID: 25238978 [PubMed - indexed for MEDLINE]

Social support quality and availability affects risk behaviors in offenders.

Recent Research Articles from UNTHSC - Fri, 04/08/2016 - 06:29

Social support quality and availability affects risk behaviors in offenders.

Health Justice. 2016;4:2

Authors: Spohr SA, Suzuki S, Marshall B, Taxman FS, Walters ST

Abstract
BACKGROUND: People involved in the justice system are at 2.5 times the risk of HIV infection compared to the general population, which is further complicated by substance abuse. The purpose of this study was to evaluate the role of social network quality and quantity on unprotected sex, criminal risk, and substance use.
METHODS: We used data from 330 drug-involved offenders. Structural equation modeling (SEM) was used to model and test path directionality and magnitude between the latent constructs of social support quality and quantity on risky behaviors.
RESULTS: The SEM indicated the latent construct of social support quality was significantly associated with reduced sexual risk behavior (β = -0.27), criminal risk (β = -0.26), and reduced substance use (β = -0.33). Additionally, the proposed model found that social support quantity was significantly positively associated with increased sexual risk behavior (β = 0.40) and substance use (β = 0.20).
CONCLUSIONS: Social support quality is an important predictor of risky behaviors; as the quality of an offender's social support increases, engagement in risky behaviors decreases. Probationers who had broader social support availability also had increased substance use and unprotected sex. Probation systems may be able to reduce substance use and STD/HIV infection risk in offenders by strengthening the quality of social support networks.

PMID: 27054059 [PubMed - as supplied by publisher]

Dermatorynchus geneae: A seldom-described first branchial arch deformity.

Recent Research Articles from UNTHSC - Thu, 04/07/2016 - 10:36

Dermatorynchus geneae: A seldom-described first branchial arch deformity.

JAAD Case Rep. 2015 Sep;1(5):283-285

Authors: McIlwee BE, Hick RW, Weis SE

PMID: 27051754 [PubMed - as supplied by publisher]

Vestiges of an Ancient Border in the Contemporary Genetic Diversity of North-Eastern Europe.

Recent Research Articles from UNTHSC - Thu, 04/07/2016 - 10:36
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Vestiges of an Ancient Border in the Contemporary Genetic Diversity of North-Eastern Europe.

PLoS One. 2015;10(7):e0130331

Authors: Neuvonen AM, Putkonen M, Översti S, Sundell T, Onkamo P, Sajantila A, Palo JU

Abstract
It has previously been demonstrated that the advance of the Neolithic Revolution from the Near East through Europe was decelerated in the northernmost confines of the continent, possibly as a result of space and resource competition with lingering Mesolithic populations. Finland was among the last domains to adopt a farming lifestyle, and is characterized by substructuring in the form of a distinct genetic border dividing the northeastern and southwestern regions of the country. To explore the origins of this divergence, the geographical patterns of mitochondrial and Y-chromosomal haplogroups of Neolithic and Mesolithic ancestry were assessed in Finnish populations. The distribution of these uniparental markers revealed a northeastern bias for hunter-gatherer haplogroups, while haplogroups associated with the farming lifestyle clustered in the southwest. In addition, a correlation could be observed between more ancient mitochondrial haplogroup age and eastern concentration. These results coupled with prior archeological evidence suggest the genetic northeast/southwest division observed in contemporary Finland represents an ancient vestigial border between Mesolithic and Neolithic populations undetectable in most other regions of Europe.

PMID: 26132657 [PubMed - indexed for MEDLINE]

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