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Neuronal injury from cardiac arrest: aging years in minutes.

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Neuronal injury from cardiac arrest: aging years in minutes.

Age (Dordr). 2014;36(4):9680

Authors: Cherry BH, Sumien N, Mallet RT

Abstract
Cardiac arrest is a leading cause of death and permanent disability. Most victims succumb to the oxidative and inflammatory damage sustained during cardiac arrest/resuscitation, but even survivors typically battle long-term neurocognitive impairment. Although extensive research has delineated the complex mechanisms that culminate in neuronal damage and death, no effective treatments have been developed to interrupt these mechanisms. Of importance, many of these injury cascades are also active in the aging brain, where neurons and other cells are under persistent oxidative and inflammatory stress which eventually damages or kills the cells. In light of these similarities, it is reasonable to propose that the brain essentially ages the equivalent of several years within the few minutes taken to resuscitate a patient from cardiac arrest. Accordingly, cardiac arrest-resuscitation models may afford an opportunity to study the deleterious mechanisms underlying the aging process, on an accelerated time course. The aging and resuscitation fields both stand to gain pivotal insights from one another regarding the mechanisms of injury sustained during resuscitation from cardiac arrest and during aging. This synergism between the two fields could be harnessed to foster development of treatments to not only save lives but also to enhance the quality of life for the elderly.

PMID: 25104136 [PubMed - indexed for MEDLINE]

ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning.

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ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning.

Age (Dordr). 2014;36(4):9685

Authors: Su C, Sun F, Cunningham RL, Rybalchenko N, Singh M

Abstract
Oxidative stress has long been implicated in the pathogenesis of various neurodegenerative disorders such as Alzheimer's disease and stroke. While high levels of oxidative stress are generally associated with cell death, a slight rise of reactive oxygen species (ROS) levels can be protective by "preconditioning" cells to develop a resistance against subsequent challenges. However, the mechanisms underlying such preconditioning (PC)-induced protection are still poorly understood. Previous studies have supported a role of ERK5 (mitogen-activated protein [MAP] kinase 5) in neuroprotection and ischemic tolerance in the hippocampus. In agreement with these findings, our data suggest that ERK5 mediates both hydrogen peroxide (H2O2)-induced PC as well as nerve growth factor (NGF)-induced neuroprotection. Activation of ERK5 partially rescued pheochromocytoma PC12 cells as well as primary hippocampal neurons from H2O2-caused death, while inhibition of ERK5 abolished NGF or PC-induced protection. These results implicate ERK5 signaling as a common downstream pathway for NGF and PC. Furthermore, both NGF and PC increased the expression of the transcription factor, KLF4, which can initiate an anti-apoptotic response in various cell types. Induction of KLF4 by NGF or PC was blocked by siERK5, suggesting that ERK5 is required in this process. siKLF4 can also attenuate NGF- or PC-induced neuroprotection. Overexpression of active MEK5 or KLF4 in H2O2-stressed cells increased Bcl-2/Bax ratio and the expression of NAIP (neuronal apoptosis inhibitory protein). Taken together, our data suggest that ERK5/KLF4 cascade is a common signaling pathway shared by at least two important mechanisms by which neurons can be protected from cell death.

PMID: 25015774 [PubMed - indexed for MEDLINE]

Cerebral palsy of the elbow and forearm.

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Cerebral palsy of the elbow and forearm.

J Hand Surg Am. 2014 Jul;39(7):1425-32

Authors: Bunata R, Icenogle K

Abstract
Management of elbow and forearm involvement in cerebral palsy has evolved over the last 3 decades with a better understanding of its neuropathophysiology, improved outcome measures, and evolving therapy protocols. Current nonoperative and surgical treatment methods are discussed. The use of standard function measuring instruments and encouragement of the participation in research will hopefully result in more accurate outcome information and, thereby, refine our techniques and rehabilitation methods.

PMID: 24969499 [PubMed - indexed for MEDLINE]

Association of hypothyroidism with low-level arsenic exposure in rural West Texas

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Gong, G. | Basom, J. | Mattevada, S. | Onger, F.
Publication year: 2015
Journal / Book title: Environmental Research

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Cancer mortality in the meat and delicatessen departments of supermarkets (1950-2006)

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Johnson, E.S. | Cardarelli, K. | Jadhav, S. | Chedjieu, I.P. | Faramawi, M. | Fischbach, L. | Ndetan, H. | Wells, T.L.-C. | Patel, K.V. | Katyal, A.
Publication year: 2015
Journal / Book title: Environment International

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Transcription Factor Brn-3b Overexpression Enhances Neurite Outgrowth in PC12 Cells Under Condition of Hypoxia

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Phatak, N.R. | Stankowska, D.L. | Krishnamoorthy, R.R.
Publication year: 2015
Journal / Book title: Cellular and Molecular Neurobiology

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Arsenic exposure, hyperuricemia, and gout in US adults

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Kuo, C.-C. | Weaver, V. | Fadrowski, J.J. | Lin, Y.-S. | Guallar, E. | Navas-Acien, A.
Publication year: 2015
Journal / Book title: Environment International

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High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: Proof-of-concept

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Gatson, J.W. | Simpkins, J.W. | Uteshev, V.V.
Publication year: 2015
Journal / Book title: Brain Research Bulletin

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AMPA receptor desensitization is the determinant of AMPA receptor mediated excitotoxicity in purified retinal ganglion cells

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Park, Y.H. | Mueller, B.H. | McGrady, N.R. | Ma, H.-Y. | Yorio, T.
Publication year: 2015
Journal / Book title: Experimental Eye Research

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Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Garitaonandia, I. | Amir, H. | Boscolo, F.S. | Wambua, G.K. | Schultheisz, H.L. | Sabatini, K. | Morey, R. | Waltz, S. | Wang, Y.-C. | Tran, H. | Leonardo, T.R. | Nazor, K. | Slavin, I. | Lynch, C. | Li, Y. | Coleman, R. | Romero, I.G. | Altun, G. | Reynolds, D. | Dalton, S. | Parast, M. | Loring, J.F. | Laurent, L.C.
Publication year: 2015
Journal / Book title: PLoS ONE

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Development of biodegradable nanocarriers loaded with a monoclonal antibody

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Gdowski, A. | Ranjan, A. | Mukerjee, A. | Vishwanatha, J.
Publication year: 2015
Journal / Book title: International Journal of Molecular Sciences

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Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Peng, X. | Wang, Q. | Mishra, Y. | Xu, J. | Reichert, D.E. | Malik, M. | Taylor, M. | Luedtke, R.R. | Mach, R.H.
Publication year: 2015
Journal / Book title: Bioorganic and Medicinal Chemistry Letters

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Neuroglobin Overexpression Inhibits AMPK Signaling and Promotes Cell Anabolism

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Cai, B. | Li, W. | Mao, X. | Winters, A. | Ryou, M.-G. | Liu, R. | Greenberg, D.A. | Wang, N. | Jin, K. | Yang, S.-H.
Publication year: 2015
Journal / Book title: Molecular Neurobiology

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Elephant (Elephas maximus) health and management in Asia: Variations in veterinary perspectives

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Miller, D. | Jackson, B. | Riddle, H.S. | Stremme, C. | Schmitt, D. | Miller, T.
Publication year: 2015
Journal / Book title: Veterinary Medicine International

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Underlying Data for Sequencing the Mitochondrial Genome with the Massively Parallel Sequencing Platform Ion Torrent™ PGM™

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Seo, S.B. | Zeng, X. | King, J.L. | Larue, B.L. | Assidi, M. | Al-Qahtani, M.H. | Sajantila, A. | Budowle, B.
Publication year: 2015
Journal / Book title: BMC Genomics

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Interaction between Nef and INI1/SMARCB1 augments replicability of HIV-1 in resting human peripheral blood mononuclear cells

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Pyeon, D. | Park, I.-W.
Publication year: 2015
Journal / Book title: Archives of Virology

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Rarity of the alzheimer disease-protective APP A673T variant in the United States

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Wang, L.-S. | Naj, A.C. | Graham, R.R. | Crane, P.K. | Kunkle, B.W. | Cruchaga, C. | Gonzalez Murcia, J.D. | Cannon-Albright, L. | Baldwin, C.T. | Zetterberg, H. | Blennow, K. | Kukull, W.A. | Faber, K.M. | Schupf, N. | Norton, M.C. | Tschanz, J.T. | Munger, R.G. | Corcoran, C.D. | Rogaeva, E. | Albert, M.S. | Albin, R.L. | Apostolova, L.G. | Arnold, S.E. | Barber, R. | Barmada, M.M. | Barnes, L.L. | Beach, T.G. | Becker, J.T. | Beecham, G.W. | Beekly, D. | Bennett, D.A. | Bigio, E.H. | Bird, T.D. | Blacker, D. | Boeve, B.F. | Bowen, J.D. | Boxer, A. | Burke, J.R. | Buxbaum, J.D. | Cairns, N.J. | Cao, C. | Carlson, C.S. | Carroll, S.L. | Chui, H.C. | Clark, D.G. | Cribbs, D.H. | Crocco, E.A. | DeCarli, C. | DeKosky, S.T. | Demirci, F.Y. | Dick, M. | Dickson, D.W. | Duara, R. | Ertekin-Taner, N. | Fallon, K.B. | Farlow, M.R. | Ferris, S. | Frosch, M.P. | Galasko, D.R. | Ganguli, M. | Gearing, M. | Geschwind, D.H. | Ghetti, B. | Gilbert, J.R. | Glass, J.D. | Graff-Radford, N.R. | Growdon, J.H. | Hamilton, R.L. | Hamilton-Nelson, K.L. | Harrell, L.E. | Head, E. | Honig, L.S. | Hulette, C.M. | Hyman, B.T. | Jarvik, G.P. | Jicha, G.A. | Jin, L.-W. | Jun, G. | Kamboh, M.I. | Karydas, A. | Kaye, J.A. | Kim, R. | Koo, E.H. | Kowall, N.W. | Kramer, J.H. | Kramer, P. | LaFerla, F.M. | Lah, J.J. | Leverenz, J.B. | Levey, A.I. | Li, G. | Lieberman, A.P. | Lopez, O.L. | Lunetta, K.L. | Lyketsos, C.G. | Mack, W.J. | Marson, D.C. | Martin, E.R. | Martiniuk, F. | Mash, D.C. | Masliah, E. | McCormick, W.C. | McCurry, S.M. | McDavid, A.N. | McKee, A.C. | Mesulam, M.M. | Miller, B.L. | Miller, C.A. | Miller, J.W. | Montine, T.J. | Morris, J.C. | Murrell, J.R. | Olichney, J.M. | Parisi, J.E. | Perry, W. | Peskind, E. | Petersen, R.C. | Pierce, A. | Poon, W.W. | Potter, H. | Quinn, J.F. | Raj, A. | Raskind, M. | Reiman, E.M. | Reisberg, B. | Reitz, C. | Ringman, J.M. | Roberson, E.D. | Rosen, H.J. | Rosenberg, R.N. | Sano, M. | Saykin, A.J. | Schneider, J.A. | Schneider, L.S. | Seeley, W.W. | Smith, A.G. | Sonnen, J.A. | Spina, S. | Stern, R.A. | Tanzi, R.E. | Thornton-Wells, T.A. | Trojanowski, J.Q. | Troncoso, J.C. | Tsuang, D.W. | Van Deerlin, V.M. | Van Eldik, L.J. | Vardarajan, B.N. | Vinters, H.V. | Vonsattel, J.P. | Weintraub, S. | Welsh-Bohmer, K.A. | Williamson, J. | Wishnek, S. | Woltjer, R.L. | Wright, C.B. | Younkin, S.G. | Yu, C.-E. | Yu, L. | Lin, C.-F. | Dombroski, B.A. | Cantwell, L.B. | Partch, A. | Valladares, O. | Hakonarson, H. | St George-Hyslop, P. | Green, R.C. | Goate, A.M. | Foroud, T.M. | Carney, R.M. | Larson, E.B. | Behrens, T.W. | Kauwe, J.S.K. | Haines, J.L. | Farrer, L.A. | Pericak-Vance, M.A. | Mayeux, R. | Schellenberg, G.D.
Publication year: 2015
Journal / Book title: JAMA Neurology

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Treatment for preventing tuberculosis in children and adolescents: A randomized clinical trial of a 3-month, 12-dose regimen of a combination of rifapentine and Isoniazid

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Villarino, M.E. | Scott, N.A. | Weis, S.E. | Weiner, M. | Conde, M.B. | Jones, B. | Nachman, S. | Oliveira, R. | Moro, R.N. | Shang, N. | Goldberg, S.V. | Sterling, T.R.
Publication year: 2015
Journal / Book title: JAMA Pediatrics

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Steady state and time resolved fluorescence studies of azadioxatriangulenium (ADOTA) fluorophore in silica and PVA thin films

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Chib, R. | Raut, S. | Shah, S. | Grobelna, B. | Akopova, I. | Rich, R. | Sørensen, T.J. | Laursen, B.W. | Grajek, H. | Gryczynski, Z. | Gryczynski, I.
Publication year: 2015
Journal / Book title: Dyes and Pigments

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In reply

Latest UNTHSC Articles in Scopus - 44 min 56 sec ago
Author(s):Hoger, S. | Lykens, K. | Beavers, S. | Katz, D. | Miller, T.
Publication year: 2015
Journal / Book title: International Journal of Tuberculosis and Lung Disease

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