Feed aggregator

Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats.

Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats.

Cardiovasc Res. 2015 Apr 24;

Authors: McCarthy CG, Wenceslau CF, Goulopoulou S, Ogbi S, Baban B, Sullivan JC, Matsumoto T, Webb RC

Abstract
AIMS: Immune system activation is a common feature of hypertension pathogenesis. However, the mechanisms that initiate this activation are not well understood. Innate immune system recognition and response to danger is becoming apparent in many cardiovascular diseases. Danger signals can arise from not only pathogens, but also damage-associated molecular patterns (DAMPs). Our first hypothesis was that the DAMP, mitochondrial DNA (mtDNA), which is recognized by Toll-like receptor 9 (TLR9), is elevated in the circulation of spontaneously hypertensive rats (SHR), and that the deoxyribonuclease enzymes responsible for its degradation, have decreased activity in SHR. Based on these novel SHR phenotypes, we further hypothesized that (1) treatment of SHR with an inhibitory oligodinucleotide for TLR9 (ODN2088) would lower blood pressure and that (2) treatment of normotensive rats with a TLR9-specific CpG oligonucleotide (ODN2395) would cause endothelial dysfunction and increase blood pressure.
METHODS AND RESULTS: We observed that SHR have elevated circulating mtDNA and diminished deoxyribonuclease I and II activity. Additionally, treatment of SHR with ODN2088 lowered systolic blood pressure. On the other hand, treatment of normotensive rats with ODN2395 increased systolic blood pressure and rendered their arteries less sensitive to acetylcholine-induced relaxation and more sensitive to norepinephrine-induced contraction. This dysfunctional vasoreactivity was due to increased cyclooxygenase and p38 mitogen-activated protein kinase activation, increased reactive oxygen species generation, and reduced nitric oxide bioavailability.
CONCLUSION: Circulating mtDNA and impaired deoxyribonuclease activity may lead to the activation of the innate immune system, via TLR9, and contribute to elevated arterial pressure and vascular dysfunction in SHR.

PMID: 25910936 [PubMed - as supplied by publisher]

C-Jun NH<inf>2</inf>-terminal kinase-induced proteasomal degradation of c-FLIP<inf>L/S</inf> and Bcl<inf>2</inf> sensitize prostate cancer cells to Fas- and mitochondria-mediated apoptosis by tetrandrine

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Chaudhary, P. | Vishwanatha, J.K.
Publication year: 2015
Journal / Book title: Biochemical Pharmacology

Access all results for your search in Scopus

Methylene blue protects astrocytes against glucose oxygen deprivation by improving cellular respiration

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Choudhury, G.R. | Winters, A. | Rich, R.M. | Ryou, M.-G. | Gryczynski, Z. | Yuan, F. | Yang, S.-H. | Liu, R.
Publication year: 2015
Journal / Book title: PLoS ONE

Access all results for your search in Scopus

Coupling between arterial pressure, cerebral blood velocity, and cerebral tissue oxygenation with spontaneous and forced oscillations

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Rickards, C.A. | Sprick, J.D. | Colby, H.B. | Kay, V.L. | Tzeng, Y.-C.
Publication year: 2015
Journal / Book title: Physiological Measurement

Access all results for your search in Scopus

Association of hypothyroidism with low-level arsenic exposure in rural West Texas

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Gong, G. | Basom, J. | Mattevada, S. | Onger, F.
Publication year: 2015
Journal / Book title: Environmental Research

Access all results for your search in Scopus

Cancer mortality in the meat and delicatessen departments of supermarkets (1950-2006)

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Johnson, E.S. | Cardarelli, K. | Jadhav, S. | Chedjieu, I.P. | Faramawi, M. | Fischbach, L. | Ndetan, H. | Wells, T.L.-C. | Patel, K.V. | Katyal, A.
Publication year: 2015
Journal / Book title: Environment International

Access all results for your search in Scopus

A population-based study of incidence and patient survival of small cell carcinoma in the United States, 1992-2010

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Dores, G.M. | Qubaiah, O. | Mody, A. | Ghabach, B. | Devesa, S.S.
Publication year: 2015
Journal / Book title: BMC Cancer

Access all results for your search in Scopus

Transcription Factor Brn-3b Overexpression Enhances Neurite Outgrowth in PC12 Cells Under Condition of Hypoxia

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Phatak, N.R. | Stankowska, D.L. | Krishnamoorthy, R.R.
Publication year: 2015
Journal / Book title: Cellular and Molecular Neurobiology

Access all results for your search in Scopus

Arsenic exposure, hyperuricemia, and gout in US adults

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Kuo, C.-C. | Weaver, V. | Fadrowski, J.J. | Lin, Y.-S. | Guallar, E. | Navas-Acien, A.
Publication year: 2015
Journal / Book title: Environment International

Access all results for your search in Scopus

High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: Proof-of-concept

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Gatson, J.W. | Simpkins, J.W. | Uteshev, V.V.
Publication year: 2015
Journal / Book title: Brain Research Bulletin

Access all results for your search in Scopus

AMPA receptor desensitization is the determinant of AMPA receptor mediated excitotoxicity in purified retinal ganglion cells

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Park, Y.H. | Mueller, B.H. | McGrady, N.R. | Ma, H.-Y. | Yorio, T.
Publication year: 2015
Journal / Book title: Experimental Eye Research

Access all results for your search in Scopus

Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Garitaonandia, I. | Amir, H. | Boscolo, F.S. | Wambua, G.K. | Schultheisz, H.L. | Sabatini, K. | Morey, R. | Waltz, S. | Wang, Y.-C. | Tran, H. | Leonardo, T.R. | Nazor, K. | Slavin, I. | Lynch, C. | Li, Y. | Coleman, R. | Romero, I.G. | Altun, G. | Reynolds, D. | Dalton, S. | Parast, M. | Loring, J.F. | Laurent, L.C.
Publication year: 2015
Journal / Book title: PLoS ONE

Access all results for your search in Scopus

Development of biodegradable nanocarriers loaded with a monoclonal antibody

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Gdowski, A. | Ranjan, A. | Mukerjee, A. | Vishwanatha, J.
Publication year: 2015
Journal / Book title: International Journal of Molecular Sciences

Access all results for your search in Scopus

Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Peng, X. | Wang, Q. | Mishra, Y. | Xu, J. | Reichert, D.E. | Malik, M. | Taylor, M. | Luedtke, R.R. | Mach, R.H.
Publication year: 2015
Journal / Book title: Bioorganic and Medicinal Chemistry Letters

Access all results for your search in Scopus

Neuroglobin Overexpression Inhibits AMPK Signaling and Promotes Cell Anabolism

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Cai, B. | Li, W. | Mao, X. | Winters, A. | Ryou, M.-G. | Liu, R. | Greenberg, D.A. | Wang, N. | Jin, K. | Yang, S.-H.
Publication year: 2015
Journal / Book title: Molecular Neurobiology

Access all results for your search in Scopus

Elephant (Elephas maximus) health and management in Asia: Variations in veterinary perspectives

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Miller, D. | Jackson, B. | Riddle, H.S. | Stremme, C. | Schmitt, D. | Miller, T.
Publication year: 2015
Journal / Book title: Veterinary Medicine International

Access all results for your search in Scopus

Underlying Data for Sequencing the Mitochondrial Genome with the Massively Parallel Sequencing Platform Ion Torrent™ PGM™

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Seo, S.B. | Zeng, X. | King, J.L. | Larue, B.L. | Assidi, M. | Al-Qahtani, M.H. | Sajantila, A. | Budowle, B.
Publication year: 2015
Journal / Book title: BMC Genomics

Access all results for your search in Scopus

Rarity of the alzheimer disease-protective APP A673T variant in the United States

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Wang, L.-S. | Naj, A.C. | Graham, R.R. | Crane, P.K. | Kunkle, B.W. | Cruchaga, C. | Gonzalez Murcia, J.D. | Cannon-Albright, L. | Baldwin, C.T. | Zetterberg, H. | Blennow, K. | Kukull, W.A. | Faber, K.M. | Schupf, N. | Norton, M.C. | Tschanz, J.T. | Munger, R.G. | Corcoran, C.D. | Rogaeva, E. | Albert, M.S. | Albin, R.L. | Apostolova, L.G. | Arnold, S.E. | Barber, R. | Barmada, M.M. | Barnes, L.L. | Beach, T.G. | Becker, J.T. | Beecham, G.W. | Beekly, D. | Bennett, D.A. | Bigio, E.H. | Bird, T.D. | Blacker, D. | Boeve, B.F. | Bowen, J.D. | Boxer, A. | Burke, J.R. | Buxbaum, J.D. | Cairns, N.J. | Cao, C. | Carlson, C.S. | Carroll, S.L. | Chui, H.C. | Clark, D.G. | Cribbs, D.H. | Crocco, E.A. | DeCarli, C. | DeKosky, S.T. | Demirci, F.Y. | Dick, M. | Dickson, D.W. | Duara, R. | Ertekin-Taner, N. | Fallon, K.B. | Farlow, M.R. | Ferris, S. | Frosch, M.P. | Galasko, D.R. | Ganguli, M. | Gearing, M. | Geschwind, D.H. | Ghetti, B. | Gilbert, J.R. | Glass, J.D. | Graff-Radford, N.R. | Growdon, J.H. | Hamilton, R.L. | Hamilton-Nelson, K.L. | Harrell, L.E. | Head, E. | Honig, L.S. | Hulette, C.M. | Hyman, B.T. | Jarvik, G.P. | Jicha, G.A. | Jin, L.-W. | Jun, G. | Kamboh, M.I. | Karydas, A. | Kaye, J.A. | Kim, R. | Koo, E.H. | Kowall, N.W. | Kramer, J.H. | Kramer, P. | LaFerla, F.M. | Lah, J.J. | Leverenz, J.B. | Levey, A.I. | Li, G. | Lieberman, A.P. | Lopez, O.L. | Lunetta, K.L. | Lyketsos, C.G. | Mack, W.J. | Marson, D.C. | Martin, E.R. | Martiniuk, F. | Mash, D.C. | Masliah, E. | McCormick, W.C. | McCurry, S.M. | McDavid, A.N. | McKee, A.C. | Mesulam, M.M. | Miller, B.L. | Miller, C.A. | Miller, J.W. | Montine, T.J. | Morris, J.C. | Murrell, J.R. | Olichney, J.M. | Parisi, J.E. | Perry, W. | Peskind, E. | Petersen, R.C. | Pierce, A. | Poon, W.W. | Potter, H. | Quinn, J.F. | Raj, A. | Raskind, M. | Reiman, E.M. | Reisberg, B. | Reitz, C. | Ringman, J.M. | Roberson, E.D. | Rosen, H.J. | Rosenberg, R.N. | Sano, M. | Saykin, A.J. | Schneider, J.A. | Schneider, L.S. | Seeley, W.W. | Smith, A.G. | Sonnen, J.A. | Spina, S. | Stern, R.A. | Tanzi, R.E. | Thornton-Wells, T.A. | Trojanowski, J.Q. | Troncoso, J.C. | Tsuang, D.W. | Van Deerlin, V.M. | Van Eldik, L.J. | Vardarajan, B.N. | Vinters, H.V. | Vonsattel, J.P. | Weintraub, S. | Welsh-Bohmer, K.A. | Williamson, J. | Wishnek, S. | Woltjer, R.L. | Wright, C.B. | Younkin, S.G. | Yu, C.-E. | Yu, L. | Lin, C.-F. | Dombroski, B.A. | Cantwell, L.B. | Partch, A. | Valladares, O. | Hakonarson, H. | St George-Hyslop, P. | Green, R.C. | Goate, A.M. | Foroud, T.M. | Carney, R.M. | Larson, E.B. | Behrens, T.W. | Kauwe, J.S.K. | Haines, J.L. | Farrer, L.A. | Pericak-Vance, M.A. | Mayeux, R. | Schellenberg, G.D.
Publication year: 2015
Journal / Book title: JAMA Neurology

Access all results for your search in Scopus

Treatment for preventing tuberculosis in children and adolescents: A randomized clinical trial of a 3-month, 12-dose regimen of a combination of rifapentine and Isoniazid

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Villarino, M.E. | Scott, N.A. | Weis, S.E. | Weiner, M. | Conde, M.B. | Jones, B. | Nachman, S. | Oliveira, R. | Moro, R.N. | Shang, N. | Goldberg, S.V. | Sterling, T.R.
Publication year: 2015
Journal / Book title: JAMA Pediatrics

Access all results for your search in Scopus

Steady state and time resolved fluorescence studies of azadioxatriangulenium (ADOTA) fluorophore in silica and PVA thin films

Latest UNTHSC Articles in Scopus - 13 hours 34 min ago
Author(s):Chib, R. | Raut, S. | Shah, S. | Grobelna, B. | Akopova, I. | Rich, R. | Sørensen, T.J. | Laursen, B.W. | Grajek, H. | Gryczynski, Z. | Gryczynski, I.
Publication year: 2015
Journal / Book title: Dyes and Pigments

Access all results for your search in Scopus
Syndicate content
Contact Us