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Effect of an acute increase in central blood volume on cerebral hemodynamics.

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Effect of an acute increase in central blood volume on cerebral hemodynamics.

Am J Physiol Regul Integr Comp Physiol. 2015 Aug 26;:ajpregu.00137.2015

Authors: Ogoh S, Hirasawa A, Raven PB, Rebuffat T, Denise P, Lericollais R, Sugawara J, Normand H

Abstract
Systemic blood distribution is an important factor involved in regulating cerebral blood flow (CBF). However, the effect of an acute change in central blood volume (CBV) on CBF regulation remains unclear. To address our question, we sought to examine the CBF and systemic hemodynamic responses to microgravity during parabolic flight. Twelve healthy subjects were seated upright and exposed to microgravity during parabolic flight. During the brief periods of microgravity mean arterial pressure was decreased (-26 ± 1%, P<0.001) despite an increase in cardiac output (+21 ± 6%, P<0.001). During microgravity central arterial pulse pressure and estimated carotid sinus pressure increased rapidly. In addition, this increase in central arterial pulse pressure was associated with an arterial baroreflex-mediated decrease in heart rate (r=-0.888, P<0.0001) and an increase in total vascular conductance (r=0.711, P<0.001). The middle cerebral artery mean blood velocity (MCA Vmean) remained unchanged throughout parabolic flight (P=0.30). During microgravity the contribution of cardiac output to MCA Vmean was gradually reduced (P<0.05) and its contribution was negatively correlated with an increase in total vascular conductance (r=-0.683, P<0.0001). These findings suggest that the acute loading of the arterial and cardiopulmonary baroreceptors by increases in CBV during microgravity results in acute and marked systemic vasodilation. Furthermore, we conclude that this marked systemic vasodilation decreases the contribution of cardiac output to CBF. These findings suggest that the arterial and cardiopulmonary baroreflex mediated peripheral vasodilation along with dynamic cerebral autoregulation counteracts a cerebral over-perfusion, that otherwise would occur during acute increases in CBV.

PMID: 26310936 [PubMed - as supplied by publisher]

Blimp-1/PRDM1 regulates the transcription of human CS1 (SLAMF7) gene in NK and B cells.

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Blimp-1/PRDM1 regulates the transcription of human CS1 (SLAMF7) gene in NK and B cells.

Immunobiology. 2015 Aug 15;

Authors: Kim JR, Mathew SO, Mathew PA

Abstract
CS1 (CRACC/CD319/SLAMF7) is a member of SLAM (Signaling Lymphocyte Activation Molecule) family receptors and is expressed on NK cells, a subset of CD8(+) T lymphocytes, activated monocytes, mature dendritic cells and activated B cells. In NK cells, CS1 signaling induces cytolytic function of NK cells against targets whereas in B cells CS1 induces proliferation and autocrine cytokine production. CS1 is upregulated in multiple myeloma cells and contributes to clonogenic growth and tumorigenicity. However, the mechanism of CS1 upregulation is unknown. In this study, we analyzed the transcriptional regulation of human CS1 gene in NK and B cells. The promoter region of CS1 contains a Blimp-1/PRDM1 binding site and relative luciferase activities of successive deletion mutants of CS1 promoter were different between Blimp-1/PRDM1-positive and Blimp-1/PRDM1-negative cells. Proximal region of CS1 promoter contains a CAAT box and atypical TATA-box that might result in common transcription initiation at -29 nucleotides upstream of the ATG translation start codon. Electrophoretic Mobility Shift Assay (EMSA) and Chromatin Immunoprecipitation (ChIP) assays revealed Blimp-1/PRDM1 binds to the CS1 promoter region. Mutating the Blimp-1/PRDM1 site at -750 to -746 decreased the transcriptional activity of CS1 promoter implicating a trans-activating function of Blimp-1/PRDM1 in human CS1 gene regulation. The finding that Blimp-1/PRDM1 enhances transcription of CS1 gene in multiple myeloma cells may help in developing novel strategies for therapeutic intervention in multiple myeloma.

PMID: 26310579 [PubMed - as supplied by publisher]

The relationship between electronic goal reminders and subsequent drug use and treatment initiation in a criminal justice setting

Latest UNTHSC Articles in Scopus - 14 hours 3 min ago
Author(s):Spohr, S.A. | Taxman, F.S. | Walters, S.T.
Publication year: 2015
Journal / Book title: Addictive Behaviors

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Total testosterone and neuropsychiatric symptoms in elderly men with Alzheimer's disease

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Author(s):Hall, J.R. | Wiechmann, A.R. | Cunningham, R.L. | Johnson, L.A. | Edwards, M. | Barber, R.C. | Singh, M. | Winter, S. | O'Bryant, S.E.
Publication year: 2015
Journal / Book title: Alzheimer's Research and Therapy

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Two novel high performing composite PMMA-CaP cements for vertebroplasty: An ex vivo animal study

Latest UNTHSC Articles in Scopus - 14 hours 3 min ago
Author(s):Aghyarian, S. | Hu, X. | Lieberman, I.H. | Kosmopoulos, V. | Kim, H.K.W. | Rodrigues, D.C.
Publication year: 2015
Journal / Book title: Journal of the Mechanical Behavior of Biomedical Materials

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Transcription Factor Brn-3b Overexpression Enhances Neurite Outgrowth in PC12 Cells Under Condition of Hypoxia

Latest UNTHSC Articles in Scopus - 14 hours 3 min ago
Author(s):Phatak, N.R. | Stankowska, D.L. | Krishnamoorthy, R.R.
Publication year: 2015
Journal / Book title: Cellular and Molecular Neurobiology

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Whole mitochondrial genome genetic diversity in an Estonian population sample

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Author(s):Stoljarova, M. | King, J.L. | Takahashi, M. | Aaspõllu, A. | Budowle, B.
Publication year: 2015
Journal / Book title: International Journal of Legal Medicine

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Minimum Information about a Biosynthetic Gene cluster

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Author(s):Medema, M.H. | Kottmann, R. | Yilmaz, P. | Cummings, M. | Biggins, J.B. | Blin, K. | De Bruijn, I. | Chooi, Y.H. | Claesen, J. | Coates, R.C. | Cruz-Morales, P. | Duddela, S. | Düsterhus, S. | Edwards, D.J. | Fewer, D.P. | Garg, N. | Geiger, C. | Gomez-Escribano, J.P. | Greule, A. | Hadjithomas, M. | Haines, A.S. | Helfrich, E.J.N. | Hillwig, M.L. | Ishida, K. | Jones, A.C. | Jones, C.S. | Jungmann, K. | Kegler, C. | Kim, H.U. | Kötter, P. | Krug, D. | Masschelein, J. | Melnik, A.V. | Mantovani, S.M. | Monroe, E.A. | Moore, M. | Moss, N. | Nützmann, H.-W. | Pan, G. | Pati, A. | Petras, D. | Reen, F.J. | Rosconi, F. | Rui, Z. | Tian, Z. | Tobias, N.J. | Tsunematsu, Y. | Wiemann, P. | Wyckoff, E. | Yan, X. | Yim, G. | Yu, F. | Xie, Y. | Aigle, B. | Apel, A.K. | Balibar, C.J. | Balskus, E.P. | Barona-Gómez, F. | Bechthold, A. | Bode, H.B. | Borriss, R. | Brady, S.F. | Brakhage, A.A. | Caffrey, P. | Cheng, Y.Q. | Clardy, J. | Cox, R.J. | De Mot, R. | Donadio, S. | Donia, M.S. | Van Der Donk, W.A. | Dorrestein, P.C. | Doyle, S. | Driessen, A.J.M. | Ehling-Schulz, M. | Entian, K.-D. | Fischbach, M.A. | Gerwick, L. | Gerwick, W.H. | Gross, H. | Gust, B. | Hertweck, C. | Höfte, M. | Jensen, S.E. | Ju, J. | Katz, L. | Kaysser, L. | Klassen, J.L. | Keller, N.P. | Kormanec, J. | Kuipers, O.P. | Kuzuyama, T. | Kyrpides, N.C. | Kwon, H.-J. | Lautru, S. | Lavigne, R. | Lee, C.Y. | Linquan, B. | Liu, X. | Liu, W. | Luzhetskyy, A. | Mahmud, T. | Mast, Y. | Méndez, C. | Metsä-Ketelä, M. | Micklefield, J. | Mitchell, D.A. | Moore, B.S. | Moreira, L.M. | Müller, R. | Neilan, B.A. | Nett, M. | Nielsen, J. | O'Gara, F. | Oikawa, H. | Osbourn, A. | Osburne, M.S. | Ostash, B. | Payne, S.M. | Pernodet, J.-L. | Petricek, M. | Piel, J. | Ploux, O. | Raaijmakers, J.M. | Salas, J.A. | Schmitt, E.K. | Scott, B. | Seipke, R.F. | Shen, B. | Sherman, D.H. | Sivonen, K. | Smanski, M.J. | Sosio, M. | Stegmann, E. | Süssmuth, R.D. | Tahlan, K. | Thomas, C.M. | Tang, Y. | Truman, A.W. | Viaud, M. | Walton, J.D. | Walsh, C.T. | Weber, T. | Van Wezel, G.P. | Wilkinson, B. | Willey, J.M. | Wohlleben, W. | Wright, G.D. | Ziemert, N. | Zhang, C. | Zotchev, S.B. | Breitling, R. | Takano, E. | Glöckner, F.O.
Publication year: 2015
Journal / Book title: Nature Chemical Biology

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MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression

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Author(s):Kpetemey, M. | Dasgupta, S. | Rajendiran, S. | Das, S. | Gibbs, L.D. | Shetty, P. | Gryczynski, Z. | Vishwanatha, J.K.
Publication year: 2015
Journal / Book title: Molecular Cancer

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Acute inhalation of vaporized nicotine increases arterial pressure in young non-smokers: a pilot study

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Author(s):Cooke, W.H. | Pokhrel, A. | Dowling, C. | Fogt, D.L. | Rickards, C.A.
Publication year: 2015
Journal / Book title: Clinical Autonomic Research

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Δ9-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids found on the gray market

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Author(s):Gatch, M.B. | Forster, M.J.
Publication year: 2015
Journal / Book title: Behavioural Pharmacology

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The effects of metal ion PCR inhibitors on results obtained with the Quantifiler<sup>®</sup> Human DNA Quantification Kit

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Author(s):Combs, L.G. | Warren, J.E. | Huynh, V. | Castaneda, J. | Golden, T.D. | Roby, R.K.
Publication year: 2015
Journal / Book title: Forensic Science International: Genetics

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Assessment of subunit-dependent direct gating and allosteric modulatory effects of carisoprodol at GABA<inf>A</inf> receptors

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Author(s):Kumar, M. | González, L.A. | Dillon, G.H.
Publication year: 2015
Journal / Book title: Neuropharmacology

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Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress

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Author(s):Ryou, M.-G. | Choudhury, G.R. | Li, W. | Winters, A. | Yuan, F. | Liu, R. | Yang, S.-H.
Publication year: 2015
Journal / Book title: Neuroscience

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Constrictor prostanoids and uridine adenosine tetraphosphate: Vascular mediators and therapeutic targets in hypertension and diabetes

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Author(s):Matsumoto, T. | Goulopoulou, S. | Taguchi, K. | Tostes, R.C. | Kobayashi, T.
Publication year: 2015
Journal / Book title: British Journal of Pharmacology

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Alcohol Sales to Youth: Data from Rural Communities Within the Cherokee Nation

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Author(s):Lynne-Landsman, S.D. | Kominsky, T.K. | Livingston, M.D. | Wagenaar, A.C. | Komro, K.A.
Publication year: 2015
Journal / Book title: Prevention Science

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Tip110 binding to U6 small nuclear RNA and its participation in pre-mRNA splicing

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Author(s):Liu, Y. | Liu, J. | Wang, Z. | He, J.J.
Publication year: 2015
Journal / Book title: Cell and Bioscience

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Contra-directional expression of serum homocysteine and uric acid as important biomarkers of multiple system atrophy severity: A cross-sectional study

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Author(s):Chen, D. | Wei, X. | Zou, J. | Wang, R. | Liu, X. | Xu, X. | Lu, J. | Wang, Z. | Tang, B. | Wang, B. | Jin, K. | Wang, Q.
Publication year: 2015
Journal / Book title: Frontiers in Cellular Neuroscience

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Vestiges of an ancient border in the contemporary genetic diversity of North-Eastern Europe

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Author(s):Neuvonen, A.M. | Putkonen, M. | Översti, S. | Sundell, T. | Onkamo, P. | Sajantila, A. | Palo, J.U.
Publication year: 2015
Journal / Book title: PLoS ONE

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Motivational tools to improve probationer treatment outcomes

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Author(s):Taxman, F.S. | Walters, S.T. | Sloas, L.B. | Lerch, J. | Rodriguez, M.
Publication year: 2015
Journal / Book title: Contemporary Clinical Trials

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